This 10-minute video lesson discusses how cytotoxic T-Cells get activated by MHC-I/antigen complexes and then proceed to kill infected cells. [Biology playlist: Lesson 56 of 71].
This 21-minute video lesson provides an introduction to helper T-Cells and their role in activating B cells. [Biology playlist: Lesson 55 of 71].
CK-12 Biology I - Honors is a high school FlexBook covering five units: Cell Biology, Genetics, Evolution, Ecology, and Physiology.
A work in progress, CK-12 Biology I Honors - Teacher's Edition complements CK-12''s Biology I Honors book covering: Introduction to Life Science; Cells; Genetics; Evolution; Ecology; and Human Biology.
A work in progress, CK-12 Biology I Honors Workbook complements its Biology I Honors FlexBook covering: Introduction to Life Science; Cells; Genetics; Evolution; Ecology; and Human Biology.
This 15-minute video provides an overview of the inflammatory response. [Biology playlist: Lesson 58 of 71].
This 16-minute video lesson looks at the role of phagocytes in innate or nonspecific immunity. It also discusses neutrophils, macrophages, and dendritic cells. MHC II. [Biology playlist: Lesson 51 of 71].
This 8-minute video lesson presents an overview of types of immune responses. It looks at the difference between innate and adaptive immunity and the differences between humoral adaptive immunity and cell-mediated adaptive immunity. [Biology playlist: Lesson 52 of 71].
Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of the case covering a number of immunological issues in the context of disease are posted on a student Web site.
This Web site, created to complement the museum's Epidemic! exhibit, provides an in-depth look at the world of infectious disease. It includes the following sections: Environmental Change looks at how a season of heavy snow and rainfall led to an outbreak of hantavirus in the Four Corners region of the southwestern U.S., and at the different habitat needs of microbes. Long-Term Changes examines how changes to the prehistoric landscape and in our living patterns since the development of agriculture, have made diseases like malaria a major threat in tropical regions. Microbes and Others looks at the three major groups of microbes (viruses, bacteria, and protozoa) and the great variety within each group. Diagnostics and Testing examines how the link between microbes and disease was first made and the many medical advances since then. Infection covers how microbes enter the body and the body's built-in defense mechanisms. Outbreak looks at the different routes microbes use to spread through a population and the work of epidemiologists. Epidemic/Pandemic explores the factors that determine whether an outbreak will become an epidemic or a pandemic. Resources is a list, organized by topic and specific disease, of more than 250 Web sites. Glossary includes nearly 200 infectious disease terms, from AIDS to WHO.
This patient education program discusses the Epstein-Barr virus which is active as infectious mononucleosis including the symptoms, diagnosis, and treatment. It also reviews the immune system response to viral infections. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute.
This patient education program discusses the Epstein-Barr virus which is active as infectious mononucleosis including the symptoms, diagnosis, and treatment. It also reviews the immune system response to viral infections. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute.
Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics.
Help the immune system fight off an infection in this interactive feature from the NOVA: "Surviving AIDS" Web site.
This lesson describes the major components and functions of the immune system and the role of engineers in keeping the body healthy (e.g., vaccinations and antibiotics, among other things). This lesson also discusses how an astronaut's immune system is suppressed during spaceflight due to stress and other environmental factors.
This activity explains what a fever is and how the immune system uses it to try and protect the body against germs. The students then explore temperature further by creating a model of a thermometer and completing a temperature conversion worksheet.
Physiology is the study of the processes of the body. This course is about the unconscious mechanics of living; the student will look at each organ system in detail and then discuss the ways in which the systems interact in order to maintain the body at an optimal state. Metabolism and homeostasis--or the maintenance of the body at a set, optimal level--will be the primary themes. Upon successful completion of this course, the student will be able to: describe the relationship between structure and function at the cellular level and relate dysfunctional states of health to problems at the cellular level when appropriate; given relevant physiological information, explain the physiological mechanisms involved; describe the concepts of homeostasis and feedback control in relationship to each organ system; use a vocabulary of physiological terms and demonstrate an ability to communicate efficiently in a medical environment; describe techniques currently in use that measure the function of organ systems. (Biology 304)
This course is an advanced undergraduate seminar based upon discussions and critical analysis of primary literature in the field of immunology. Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease specific immune evasion and the mechanisms used by pathogens to prevail over their host's immune systems are discussed. What these host-pathogen interactions reveal about the normal function of the immune system and about basic cell biological processes, such as protein maturation and degradation, are also considered.
Immunology is the study of our immune system, a highly sophisticated system that defends us against all disease-causing invaders by identifying and neutralizing such threats. As with any system in our body, when the immune system malfunctions, disease can result. In this course the student will take a look at what happens when an inappropriate immune response takes place. (Biology 407)
General Learning Objectives for Immunology
1. To understand the structural and genetic basis of diversity and specificity of immunoglobulins and T cell receptors.
2. To understand the utility of antibodies in many clinical tests for proteins, hormones, etc.
3. To understand the events that hallmark the antigen-independent and antigen-dependent phases of B cell differentiation.
4. To understand the diversity of MHC molecules, and how that diversity differs from immunoglobulin and T cell receptor diversity.
5. To understand how MHC molecules present antigens, and how antigens are processed to before presentation.
6. To understand positive and negative T cell selection in the thymus, and how those events influence the final T cell repertoire.
7. To understand the requirements for T cell activation by antigen, and how the nature of the antigen presenting cell influences the outcome of antigen recognition.
8. To understand that transplantation reactions are mainly the result of T cell recognition of allogeneic MHC molecules.
9. To understand how the effector functions of antibodies, T cells, macrophages, neutrophils, and NK cells can eliminate pathogens or lead to pathology.
10. To understand the function of CD4+ Th1, CD4+ Th2 cells, and CD8+ cytotoxic T cells in the immune response.
11. To appreciate the multiple roles of cytokines and chemokines in mediating interactions between leukocytes and other leukocytes and between leukocytes and other types of cells.
12. To understand how cells in both innate and acquired immunity can encounter a pathogen first at one site, and then fight an infection at some distal site.
