Experiments with the Structure and Function of DNA

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Abstract:: This exercise will give students an interactive opportunity to develop their understanding of DNA structure, how it is packaged into chromosomes, and the mechanisms of transcription and translation.

Subject:: Science and Technology
Grade Level:: Secondary, Post-secondary
Collection:: Association for Biology Laboratory Education (ABLE)

"The Fountain of Life: From Dolly to Customized Embryonic Stem Cells, Fall 2007"

(Complete Item Description)

Abstract:: " During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which have proved to involve reversible alterations to both DNA and to proteins that bind DNA, are known as epigenetic, to distinguish them from genetic alterations to DNA sequence. In this course we will explore such epigenetic changes and study different approaches that can return a differentiated cell to an embryonic state in a process referred to as epigenetic reprogramming, which will ultimately allow generation of patient-specific stem cells and application to regenerative therapy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching."

Subject:: Science and Technology
Grade Level:: Post-secondary
Collection:: MIT OpenCourseWare

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Molecular Clocks: Proteins That Evolve at Different Rates

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Abstract:: From The Human Evolution Coloring Book by Adrienne Zihlman, four different proteins from humans and horses are compared in this graphic and article, and the reasons each protein evolves at its own characteristic rate are discussed. Each protein is useful for measuring evolutionary change over a different time scale.

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Experiments with the Structure and Function of DNA

"The Fountain of Life: From Dolly to Customized Embryonic Stem Cells, Fall 2007"

Molecular Clocks: Proteins That Evolve at Different Rates

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Browse: Keyword: Histone

You searched for:

Refine Your Search

Experiments with the Structure and Function of DNA

"The Fountain of Life: From Dolly to Customized Embryonic Stem Cells, Fall 2007"

Molecular Clocks: Proteins That Evolve at Different Rates

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