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  • g-protein-coupled-receptors
AKT inactivation mediated by a ‘PP2A switch’ after GqPCR activation
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gq protein-coupled receptors (GqPCRs) are membrane bound proteins that transmit signals from outside the cell to internal signaling pathways. One of these pathways is the PI3K/AKT pathway, which plays roles in cellular proliferation, survival, metabolism, and differentiation. PI3K/AKT dysregulation is also often implicated in cancers. A previous study determined that activating GqPCRs in certain cells inactivated AKT, which led to a specific type of cell death, JNK-dependent apoptosis. This unique signal seems to play an important role in physiological and pathological events like pituitary development and cardiac hypertrophy. Now, a new study determined that the mechanism of this AKT inactivation relies on another signaling-related protein, PP2A. When the GqPCRs are not activated, a fraction of PP2A "c" subunit is in a dimer complex with another protein, IGBP1 and they are bound to the p85 subunit of PI3K, causing its activation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
01/11/2022
Discriminating between melatonin signaling at the cell surface and neuronal mitochondria
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The physiological effects of melatonin are far reaching, from acting as an neuroprotective agent to regulating circadian rhythms and sleep cycles. An imbalance of this hormone has even been linked to neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s. The precise molecular mechanism by which melatonin exerts these effects, however, remains a mystery. To shed light on this process, a team of researchers has developed a melatonin-like compound that is unable to penetrate the cell membrane and binds only to cell-surface receptors. Melatonin’s physiological effects on the brain are controlled by the lock-and-key-like properties of this hormone and its receptors. When melatonin binds to its corresponding receptor, a biochemical signal is sent into the cell. But recent data suggests that this interaction may also occur inside the cell, itself. Specifically, on mitochondria within brain cells..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019