DNA Microarrays: Background, Interactive Databases, and Hands-on Data Analysis

Abstract:: DNA microarrays are influencing many areas of biology. DNA microarrays allow investigators to measure simultaneously the activity of every gene in a genome. This paper provides the reader with background information, a set of interactive questions, and most importantly, free software (MAGIC Tool) for use in the undergraduate curriculum. MAGIC Tool (www.bio.davidson.edu/MAGIC) resources allow the user to understand how DNA microarray data are analyzed by providing raw data, instructions, mathematical supplements, and free software that works on all computer platforms. MAGIC Tool facilitates the incorporation of microarrays into any upper level biology course.

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Incorporating Original Genomics Research into Genetics and Molecular Biology Courses

Abstract:: Genomics and bioinformatics have revolutionized biology over the past few years, but their impact on education has lagged. A new revolution is possible in the undergraduate curriculum. We have found novel ways to incorporate genomics research into the laboratory components of several courses. In this chapter, we show how we accomplish the typical skill development goals in a genetics or molecular biology course while accomplishing novel research, and provide the protocols for three such research projects that can be modified to suit the course goals or the instructor's research interests.

Abstract:: Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts.