Why has it been easier to develop a vaccine to eliminate polio than to control influenza or AIDS? Has there been natural selection for a 'language gene'? Why are there no animals with wheels? When does 'maximizing fitness' lead to evolutionary extinction? How are sex and parasites related? Why don't snakes eat grass? Why don't we have eyes in the back of our heads? How does modern genomics illustrate and challenge the field? This course analyzes evolution from a computational, modeling, and engineering perspective. The course has extensive hands-on laboratory exercises in model-building and analyzing evolutionary data.
Why has it been easier to develop a vaccine to eliminate polio than to control influenza or AIDS? Has there been natural selection for a 'language gene'? Why are there no animals with wheels? When does 'maximizing fitness' lead to evolutionary extinction? How are sex and parasites related? Why don't snakes eat grass? Why don't we have eyes in the back of our heads? How does modern genomics illustrate and challenge the field? This course analyzes evolution from a computational, modeling, and engineering perspective. The course has extensive hands-on laboratory exercises in model-building and analyzing evolutionary data.
In 1918 and 1919, the Spanish influenza killed 550,000 people in the United States and 20 to 40 million worldwide. In a 1982 interview with Laurie Mercier, Loretta Jarussi of Bearcreek, Montana, described how people would pass through that tiny town seemingly healthy, only to be reported dead two days later. Her father went undiagnosed for many weeks and had plans to go to a nearby hot springs to rest. She believed that her father's death was averted only because the son of the local doctor was an army doctor who recognized flu symptoms that others missed.
Watson and Crick noted that the size of a viral genome was insufficient to encode a protein large enough to encapsidate it and reasoned, therefore that a virus shell must be composed of multiple, but identical subunits. Today, high resolution structures of virus capsids reveal the basis of this genetic economy as a highly symmetrical structure, much like a geodesic dome composed of protein subunits. Crystallographic structures and cryo-electron microscopy reconstructions combined with molecular data are beginning to reveal how these nano-structures are built. Topics covered in the course will include basic principles of virus structure and symmetry, capsid assembly, strategies for enclosing nucleic acid, proteins involved in entry and exit, and the life cycles of well understood pathogens such as HIV, influenza, polio, and Herpes. A review of cutting edge structural methods is also covered.
In 1918 and 1919 the Spanish influenza killed more humans than any other disease in a similar period in the history of the world. In the United States a quarter of the population (25 million people or more) contracted the flu; 550,000 died. In the early 1980s, when historian Charles Hardy did interviews for the Philadelphia radio program "The Influenza Pandemic of 1918," he was struck by the painful memories as many older Philadelphians recalled the inability of the city to care for the dead and dying. In these excerpts from Hardy's radio program, Clifford Adams, an African American from the South; Anna Lavin, a Jewish immigrant; Anne Van Dyke and Elizabeth Struchesky; and Louise Abruchezze, an Italian immigrant, discussed their shared experience in Philadelphia--shocked by the scale of the influenza outbreak, none could fathom the lack of respect shown for those who had died.
In 1918 the Spanish influenza hit the United States and then the rest of the world with such swiftness that it sometimes went unnoticed until it had already passed. By mid-1919 it had killed more people than any other disease in a similar period in the history of the world. Kentucky coal miner Teamus Bartley was interviewed at ninety-five years of age and vividly recalled the impact of the flu pandemic on his community. With a dearth of healthy laborers, the mines shut down for six weeks in 1918 and miners went from digging coal to digging graves.
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