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Remix and Share
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(Complete Item Description)
- Abstract:
The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
- Subject:
- Science and Technology
- Grade Level:
- Post-secondary
- Collection:
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MIT OpenCourseWare
Read the Fine Print
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(Complete Item Description)
- Abstract:
This patient education program explains cystic fibrosis or CF, including the causes, symptoms, diagnosis, treatments, prevention, and key facts about the disease. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute.
- Subject:
- Science and Technology
- Grade Level:
- Post-secondary
- Collection:
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H.E.A.L.
Read the Fine Print
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(Complete Item Description)
- Abstract:
This patient education program explains cystic fibrosis or CF, including the causes, symptoms, diagnosis, treatments, prevention, and key facts about the disease. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute.
- Subject:
- Science and Technology
- Grade Level:
- Post-secondary
- Collection:
-
H.E.A.L.
Remix and Share
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(Complete Item Description)
- Abstract:
" In this class, students engage in independent research projects to probe various aspects of the physiology of the bacterium Pseudomonas aeruginosa PA14, an opportunistic pathogen isolated from the lungs of cystic fibrosis patients. Students use molecular genetics to examine survival in stationary phase, antibiotic resistance, phase variation, toxin production, and secondary metabolite production. Projects aim to discover the molecular basis for these processes using both classical and cutting-edge techniques. These include plasmid manipulation, genetic complementation, mutagenesis, PCR, DNA sequencing, enzyme assays, and gene expression studies. Instruction and practice in written and oral communication are also emphasized. WARNING NOTICE The experiments described in these materials are potentially hazardous and require a high level of safety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no responsibility, liability, or risk for the content or implementation of any of the material presented. Legal Notice "
- Subject:
- Science and Technology
- Grade Level:
- Post-secondary
- Collection:
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MIT OpenCourseWare
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