This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Dysregulation of the IL-6-induced JAK/STAT cascade is associated with severe inflammatory and proliferative diseases. The cascade is normally tightly controlled by proteins such as the feedback inhibitor SOCS3 and the tyrosine phosphatase SHP2. SOCS3 increases the stability of late IL-6-induced STAT3 activation across cells with different STAT3 levels and reduces the signal magnitude. but whether SHP2 similarly affects robustness and information transfer remains unclear. Researchers recently used multiplexed single-cell analyses and information theory approaches to clarify SHP2’s roles. They found that SHP2 improved the robustness of STAT3 activation under basal conditions (in the absence of the cytokine IL-6) and during early IL-6 signalling levelling the degree of activation across cells with heterogeneous expression levels of STAT3. However, it did not affect the robustness of late IL-6-induced STAT3 activation..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 10/13/2021