This course will guide graduate students through the process of using rapid prototyping and CAD/CAM devices in a studio environment. The class has a theoretical focus on machine use within the process of design. Each student is expected to have completed one graduate level of design computing with a full understanding of solid modeling in CAD. Students are also expected to have completed at least one graduate design studio.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Femoroacetabular impingement, or F**-**A**-**I, is a condition known to cause hip pain in young adults. Open surgical hip dislocation was initially the gold-standard treatment for FAI. But arthroscopic surgery is becoming increasingly common. Unfortunately, few high-level trials have evaluated the efficacy of surgical correction for FAI. To address that gap, researchers conducted a randomized controlled trial comparing osteochondroplasty to lavage with or without labral repair for the treatment of F**-**A**-**I. The lower reoperation rate observed among patients undergoing osteochondroplasty supports arthroscopic surgery as an effective treatment option for young adults with hip impingement. The study recruited 220 male and female patients aged 18 to 50 years with non-arthritic F**-**A**-**I who were deemed suitable for surgical treatment. Patients were randomized to one of two groups. In the osteochondroplasty group, impingement lesions were resected using fluoroscopic guidance..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Calcineurin is a serine/threonine phosphatase that serves as a critical bridge between calcium signaling and the phosphorylation states of numerous important substrates. But despite being studied for approximately 40 years, exactly how calcineurin is activated in humans and other organisms is not yet fully understood. Structurally, calcineurin is a heterodimer expressed as three different isoforms: α, β, and γ each featuring a catalytic domain, a B chain binding helix, the regulatory domain, an autoinhibitory domain, and an unstructured C-terminal domain of unknown function. Disorder is a key hallmark of calcineurin’s structure. The intrinsically disordered regulatory domain could facilitate the rapid activation of calcineurin during calcium signaling. Increasing evidence suggests that calcineurin is a vital component of various signaling pathways. But even more work is needed to understand calcineurin’s versatility including how certain substrates bind to calcineurin..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.