Principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.

The purpose of this activity is to introduce students to the concept of the engineering design process and to teach them how to apply it. In "Broken Bones," students will explore the steps of the engineering design process. They will first receive some background instruction about biomedical engineering or bioengineering. Then they will learn about material selection and material properties by using a guide created for them. Students will then break into small groups and brainstorm. Each student group is assigned a specific design problem. Students will be given materials and asked to create a prototype. To finish, students will communicate their solution through a poster presentation.

" This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials. Student project materials are drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants."

Electrical, optical, magnetic, and mechanical properties of metals, semiconductors, ceramics and polymers. Discussion of roles of bonding, structure (crystalline, defect, energy band and microstructure) and composition in influencing and controlling physical properties. Case studies drawn from a variety of applications including semiconductor diodes, optical detectors, sensors, thin films, biomaterials, composites, and cellular materials.

This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.

This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.

The objective of this course is to introduce large-scale atomistic modeling techniques and highlight its importance for solving problems in modern engineering sciences. We demonstrate how atomistic modeling can be used to understand how materials fail under extreme loading, involving unfolding of proteins and propagation of cracks.

Designed as a freshmen seminar course, faculty from various School of Engineering departments describe the research and educational opportunities specific to and offered by their departments. Background lectures by the 20.010J staff introduce students to the fundamental scientific basis for bioengineering. Specially produced videos provide additional background information that is supplemented with readings from newspaper and magazine articles. Bioengineering at MIT is represented by the diverse curricula offered by most Departments in the School of Engineering. This course samples the wide variety of bioengineering options for students who plan to major in one of the undergraduate Engineering degree programs. The beginning lectures describe the science basis for bioengineering with particular emphasis on molecular cell biology and systems biology. Bioengineering faculty will then describe the bioengineering options in a particular engineering course as well as the type of research conducted by faculty in the department.

Designed as a freshmen seminar course, faculty from various School of Engineering departments describe the research and educational opportunities specific to and offered by their departments. Background lectures by the BE.010J staff introduce students to the fundamental scientific basis for bioengineering. Specially produced videos provide additional background information that is supplemented with readings from newspaper and magazine articles.

Introduction to the interactions between cells and surfaces of biomaterials. Surface chemistry and physics of selected metals, polymers, and ceramics. Surface characterization methodology. Modification of biomaterials surfaces. Quantitative assays of cell behavior in culture. Biosensors and microarrays. Bulk properties of implants. Acute and chronic response to implanted biomaterials. Topics in biomimetics, drug delivery, and tissue engineering. Laboratory demonstrations.

Phenomenology of mechanical behavior of materials at the macroscopic level. Relationship of mechanical behavior to material structure and mechanisms of deformation and failure. Topics include: elasticity, viscoelasticity, plasticity, creep, fracture, and fatigue. Case studies and examples drawn from a variety of classes of materials including: metals, ceramics, polymers, thin films, composites, and cellular materials.

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.

This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.