Linear elastic and elastic-plastic fracture mechanics. Experimental methods. Microstructural effects on fracture in metals, ceramics, polymers, thin films, biological materials and composites. Toughening mechanisms. Crack growth resistance and creep fracture. Interface fracture mechanics. Fatigue damage and dislocation substructures in single crystals. Stress- and strain-life approach to fatigue. Fatigue crack growth models and mechanisms. Variable amplitude fatigue. Corrosion fatigue. Case studies of fracture and fatigue in structural, bioimplant, and microelectronic components.
Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.
Designed as a freshmen seminar course, faculty from various School of Engineering departments describe the research and educational opportunities specific to and offered by their departments. Background lectures by the 20.010J staff introduce students to the fundamental scientific basis for bioengineering. Specially produced videos provide additional background information that is supplemented with readings from newspaper and magazine articles. Bioengineering at MIT is represented by the diverse curricula offered by most Departments in the School of Engineering. This course samples the wide variety of bioengineering options for students who plan to major in one of the undergraduate Engineering degree programs. The beginning lectures describe the science basis for bioengineering with particular emphasis on molecular cell biology and systems biology. Bioengineering faculty will then describe the bioengineering options in a particular engineering course as well as the type of research conducted by faculty in the department.
Designed as a freshmen seminar course, faculty from various School of Engineering departments describe the research and educational opportunities specific to and offered by their departments. Background lectures by the BE.010J staff introduce students to the fundamental scientific basis for bioengineering. Specially produced videos provide additional background information that is supplemented with readings from newspaper and magazine articles.
Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework.
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