More advanced treatment of biochemical mechanisms that underlie biological processes. Emphasis on experimental methods used to unravel these processes, and how these processes fit into the cellular context and coordinate regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and structure and function of nucleic acids.
This exercise allows students to investigate the genetic control of a biosynthetic pathway: the production of the red pigment prodigiosin by the bacterium Serratia marcescens. The students perform feeding trials with mutant strains to examine the genetic control of this biosynthetic pathway. Auxotrophic strains of the bacteria which are blocked at different places in the pathway exhibit different colors, the wild-type is a deep red color. Pairwise feeding trials enable the students to determine which strains are blocked at which point in the pathway. Students will then use an explanatory system to determine the pathway's shape and learn about its genetic control.
No restrictions on your remixing, redistributing, or making derivative works.
Give credit to the author, as required.
Your remixing, redistributing, or making derivatives works comes with some
restrictions, including how it is shared.
Your redistributing comes with some restrictions. Do not remix or make
derivative works.
Copyrighted materials, available under Fair Use and the TEACH Act for US-based
educators, or other custom arrangements. Go to the resource provider to see
their individual restrictions.
