More advanced treatment of biochemical mechanisms that underlie biological processes. Emphasis on experimental methods used to unravel these processes, and how these processes fit into the cellular context and coordinate regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and structure and function of nucleic acids.
Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature.
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