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AIP1 inhibits the NOX4-induced NLRP3/NLRP6 imbalance and suppresses neovascularization in mice
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Healthy corneas are clear and lack blood vessels, but injuries like alkali burns can trigger neovascularization. This serious complication reduces the patient’s vision and is the leading cause of failure in corneal transplants. Previous studies have suggested that AIP1 (Apoptosis signal-regulating kinase 1-interacting protein) is involved in inflammatory neovascularization induction and that NOX4 (NADPH oxidase 4) is activated by alkali burns. NOX4 can produce reactive oxygen species (ROS) which unbalance the expression of the inflammation-related proteins NLRP3 and NLRP6 (NLR family pyrin domain containing 3 and 6). Researchers recently used a mouse model to examine how AIP1 and NOX4 are related to NLRP3/NLRP6 after corneal alkali burns. Corneal alkali burns decreased AIP1 expression and increased the expression of two pro-angiogenic proteins, clv-IL-1β (cleaved interleukin-1β) and VEGFa (vascular endothelial growth factor A)..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
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Research Square
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Date Added:
05/18/2022
CAII helps tumor endothelial cells survive in a lactic acid-rich environment
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cancer cell growth depends on the production of new blood vessels by tumor endothelial cells in a process called angiogenesis. But the growing cancer cells produce large amounts of lactic acid as a byproduct of glucose breakdown. How tumor endothelial cells are able to survive in this toxic environment is unclear. In a recent study, researchers sought to uncover the mechanism of tumor endothelial cell survival in a lactic acid-rich tumor microenvironment. Using genetics and proteomics, they compared the RNA and protein levels of pH-regulating proteins in tumor endothelial cells to those in normal endothelial cells. They found that carbonic anhydrase 2 (CAII), an important pH regulator, was elevated in tumor endothelial cells, which was induced through the VEGF signaling pathway. Blocking CAII in tumor endothelial cells decreased cell survival in lactic acid conditions, and treating tumor-bearing mice with a CAII inhibitor had decreased lung metastasis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
Provider:
Research Square
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Video Bytes
Date Added:
10/29/2020
Computational model could help streamline angiogenesis-based therapies
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Angiogenesis, the formation of new blood vessels, is a popular target of various therapies. Some therapies, like those used in tissue engineering, are designed to promote angiogenesis and new tissue growth, while other therapies, such as those designed to fight cancer, aim to suppress angiogenesis— a lifeline for tumor cells. Unfortunately, these therapies aren’t always effective. Now, a new mathematical model could help researchers understand what molecular levers to pull to effectively modulate angiogenesis. Trained on published experimental data, the model predicted the effects of activating two common targets of angiogenesis-based therapies: vascular endothelial growth factor, or VEGF, and fibroblast growth factor, or FGF. Computational experiments showed that the two factors modify both the ERK signaling pathway, which is linked to cell proliferation, and the Akt signaling pathway, which is associated with cell survival and migration..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Reading
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Research Square
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Date Added:
11/03/2020
The ESM1 gene boosts endothelial cell differentiation, opening the door to new vascular therapies
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Scientists have uncovered new details about endothelial cell differentiation that could lead to better management of vascular disease. Endothelial cells are often damaged in conditions like coronary artery disease. This damage can be repaired through the transplantation of healthy endothelial cells. But acquiring these cells at the quantities and purity needed for therapeutic transplantation is no easy task. To help solve this problem, the researchers took a closer look at the molecular factors that direct stem cells to adopt an endothelial phenotype. The team started by isolating mononuclear cells from just 1 mL of blood. They later reprogrammed these cells into induced pluripotent stem cells. To accomplish this, they used an optimized, non-integrating protocol – with very good results. The stem cells were then differentiated into endothelial cells, and the researchers tracked gene expression throughout the process..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
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Research Square
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Date Added:
09/20/2019
Engineering transplantable vascular tissue with sound
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Sound waves. They bring music to our ears, help doctors peer inside our bodies, and even allow us to “see” underwater. Now, scientists are using these versatile packets of vibrating energy for a new application: growing functional, transplantable blood vessels right on the benchtop. These engineered tissues can be used to repair injuries caused by diminished blood flow from blood clots or other blockages. But there’s a lot to consider when fabricating therapeutic blood vessels. There are biological and mechanical attributes that are tricky to get right. The body’s vasculature is complex and multiscale, and a precise geometric arrangement is needed for efficient perfusion. Vessels are also composed of multiple cell types, which need to be well integrated to function. To engineer tissues that meet these requirements, scientists developed a new acoustophoretic cell patterning technique. The method uses sound waves to precisely align cells into user-defined patterns..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider Set:
Video Bytes
Date Added:
09/20/2019
Exosomes as mediators of intercellular communication in prostate cancer
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Prostate cancer remains the second leading cause of cancer death in men, although the mechanisms of its progression are still debated. Extracellular vesicles are critical mediators of communication between prostate cancer cells and their surrounding cells and can influence malignancy. For example, prostasomes released from prostate cancer cells contain factors that promote cell survival and tumor progression, while large oncosomes support target cell reprogramming by delivering molecules related to cell growth, proliferation, and movement or RNA processing. Smaller exosomes can also induce reprogramming by shuttling a wide variety of proteins and nucleic acids. The numbers, cargoes, and structures of exosomes can change depending on prostate health or the cancer stage, which makes these vesicles and their contents good biomarkers, especially since they can be sampled non-invasively from body fluids. Exosomes’ ability to deliver materials to target cells can also be exploited to achieve targeted therapies..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
03/01/2022
Exosomes in pregnancy and their potential as new diagnostic markers and therapeutics targets
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Extracellular vesicles (EVs) are small membrane-bound particles that facilitate communication between cells. They do this by carrying cargo such as proteins, microRNAs, and other signaling molecules between cells. EVs come in a variety of sizes, the smallest of which are called exosomes. Many essential physiological functions are mediated by EVs, including pregnancy. The umbilical cord, placenta, amniotic fluid, and amniotic membranes can all release exosomes. Exosomes play roles in egg implantation, embryo formation, and fetal-maternal communication and can even influence both male and female fertility. Angiogenesis — or the formation of new blood vessels — during pregnancy is also largely regulated by exosomes. The contents of exosomes influence pregnancy-related disorders including gestational diabetes mellitus, preterm birth, and fetal growth restriction..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
Provider:
Research Square
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Video Bytes
Date Added:
05/18/2022
Extracellular vesicles from tumor endothelial cells promote cancer progression
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Angiogenesis, the process of new blood vessel formation, is a critical step in tumor formation and development. In addition to enabling the growth of individual tumors, angiogenesis helps tumor cells metastasize to distant organs, which makes the factors involved in angiogenesis potential targets for cancer therapies. For example, small enclosed sacs called extracellular vesicles (EVs) that are released from tumor cells can promote angiogenesis. These EVs encapsulate proteins and RNA molecules that can activate nearby endothelial cells in the tumor microenvironment. In turn, the endothelial cells release their own EVs, whose contents may help remodel the extracellular matrix and regulate immunity to facilitate tumor progression. EVs’ ability to deliver materials while evading immune surveillance is especially promising for cancer treatment. Specifically, EVs can be engineered to carry cancer-fighting drugs or small RNA molecules that silence certain genes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
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Research Square
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Date Added:
04/14/2023
Hypoxia induces neutrophil extracellular trap formation to drive gastric cancer growth
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gastric cancer remains difficult to treat, but a better understanding of its mechanism might lead to better therapies. An inflammatory state characterized by neutrophil activity is known to promote gastric cancer progression. However, it’s unclear how neutrophil extracellular traps (NETs) in the tumor immune microenvironment influence tumor growth. To learn more, researchers recently analyzed NET formation in gastric cancer. Serum NET markers were elevated in patients with gastric cancer, and higher NET marker levels were associated with worse survival. In addition, more NETs formed in gastric cancer tissues than in adjacent normal tissues. In vitro, a hypoxic environment (like that in tumors) caused gastric cancer cells to release neutrophil-recruiting factors. Hypoxia also triggered the cytoplasmic translocation of HMGB1 in gastric cancer cells and subsequent HMGB1 release. This extracellular HMGB1 then activated the TLR4/p38 MAPK pathway in neutrophils to induce NET formation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
Provider:
Research Square
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Date Added:
05/08/2023
Medicine: Rethinking Cancer
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TED Studies, created in collaboration with Wiley, are curated video collections — supplemented by rich educational materials — for students, educators and self-guided learners. The speakers in Rethinking Cancer give the talk of their lives about the prevention, detection and treatment of one of the leading causes of death worldwide: cancer. In this course, you’ll question fundamental concepts about what cancer is and rethink how cancer research should be conducted.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Reading
Teaching/Learning Strategy
Provider:
TED
Provider Set:
TED Studies
Author:
Paul Moss
Date Added:
01/06/2017
Melanoma cells activate nearby fibroblasts to drive cancer progression
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Melanoma is a dangerous skin cancer that can quickly become resistant to treatment, in part through interactions between cancer cells and their surroundings. For example, melanoma cells can secrete factors that activate fibroblasts in the tumor microenvironment, and the resulting cancer-associated fibroblasts (CAFs) facilitate cancer progression. However, the exact interactions between melanoma cells and CAFs remain unclear. To learn more, researchers recently cultured normal human fibroblasts with melanoma cells or melanoma-secreted proteins in vitro. They confirmed that the normal fibroblasts became CAFs with enhanced migration, invasion, and matrix protein degradation abilities, which are properties that facilitate cancer progression. The levels of immune molecules called cytokines and proteins related to blood vessel formation were also upregulated in the CAFs, and secretion of lactate, a common end product of cancer cell metabolism, was increased..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
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Research Square
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Date Added:
05/18/2022
Migrasomes deliver messages from migrating cells
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Migrasomes are newly discovered extracellular vesicles that can mediate communication between cells. These unique vesicles form exclusively at the rear of migrating cells with the help of a protein called TSPAN4. After they’re left behind, the migrasomes and their contents can be captured by nearby cells and affect the recipient cells’ behavior. They can also serve as “breadcrumb trails” that mark the paths of their migrating parent cells. Migrasomes participate in both health and disease. For example, they can dispose of damaged mitochondria to maintain healthy cells and they help establish left–right patterning in zebrafish embryos by releasing the protein CXCL12 to recruit dorsal forerunner cells (DFCs). However, migrasomes can also deliver molecules that promote tumor growth and metastasis and migrasomes released from platelets promote blood clotting after SARS-CoV-2 infection..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
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Diagram/Illustration
Reading
Provider:
Research Square
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Date Added:
05/15/2023
New dual-function drug targets lung cancer
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Researchers from Sun-Bio Medical Device Company have designed a new drug that delivers a one-two punch to lung cancer cells. Shown to be potent against human tumor cells grafted onto nude mice, the drug is a promising candidate for treating lung cancer in humans. Despite advances in cancer diagnosis and treatment, lung cancer remains the deadliest form of the disease. Surgery and chemotherapy are two go-to methods for treatment. Unfortunately, neither is 100% effective. That has many researchers turning to more precise, molecular-level targeting strategies—most notably by using antibodies. Researchers can design antibodies to lock onto and disrupt receptors that keep cancer cells alive and replicating. And not just one type at a time. So-called bispecific antibodies seek out two targets at once and have proven therapeutically more effective than their single-target counterparts..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Chemistry
Physical Science
Material Type:
Diagram/Illustration
Reading
Provider Set:
Video Bytes
Date Added:
09/20/2019
New target for cutting off blood supply to liver tumors
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer. One of the distinguishing features of HCC tumors is their dense network of blood vessels. This makes Angiopoetin-2, a protein that promotes vessel formation in tumors, an attractive target for fighting HCC. In a recent study, researchers discovered a novel route HCC tumors use to release Angiopoetin-2. Test-tube experiments revealed that tumor cells wrapped Angiopoetin-2 in tiny sacs called exosomes. and delivered them to cells derived from human umbilical cord, which boosted blood vessel formation. Gene editing allowed the team to knock out the gene controlling Angiopoetin-2, which, once delivered, significantly reduced the generation of new lifelines from healthy cells. The results point to a new way of disrupting tumor growth. and could lead to new therapies for cancer of the liver and other organs..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/29/2020
Plasmodium infection inhibits tumor angiogenesis in a murine model of hepatocellular carcinoma
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Treatments for HCC are limited, and the survival rate remains low. Now, a new study suggests a novel treatment that relies on a unique method of preventing tumor growth. The study focuses on Plasmodium, the parasite that causes malaria. Interestingly, infection with Plasmodium can boost immune cell function, and Plasmodium infection is known to have an antitumor effect. Researchers used a mouse model of HCC to examine the effect of Plasmodium infection on HCC progression. Their results showed that Plasmodium infection efficiently inhibited tumor progression and prolonged survival. Plasmodium infection suppressed tumor angiogenesis, cutting off the tumor’s blood supply. Plasmodium infection also reduces the number of tumor-associated macrophages through malarial pigment. These macrophages help to build blood vessels within tumors..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
11/12/2020
Potential roles of angiogenesis inhibitors in cancer treatment
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Tumor growth relies upon the production of new blood vessels, also known as angiogenesis, to supply adequate oxygen and nutrients to the cells. Angiogenesis blockade therapy was thus developed to impair blood vessel growth and cut off this supply. This is accomplished with the use of medicines targeting pro-angiogenic factors such as vascular-endothelium growth factor (VEGF), fibroblast growth factor (FGF), and stem cell factor (SCF). For example, bevacizumab is a monoclonal antibody that targets VEGF and has shown promise in combating non-small-cell lung cancer, but the use of angiogenesis inhibitors has also been linked to an increase in local tumor invasiveness and the spread of cancer to other parts of the body. New evidence suggests that these issues can be diminished by administering anti-angiogenic agents in combination with other strategies..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022
Potential value of circular RNAs for glioblastoma multiforme diagnosis and treatment
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Glioblastoma multiforme (GBM) is a deadly brain cancer that affects both adults and children. GBM remains mostly incurable because of the nonuniform nature of GBM cells and the numerous mechanisms involved. However, noncoding RNA molecules called circular RNAs (circRNAs) may be valuable targets for GBM treatment, because these molecules can promote or suppress cancer-related processes like cell proliferation, cell death, invasion, and chemoresistance. For example, various circRNAs can regulate pathways that are dysregulated in GBM, such as the PI3K/Akt/mTOR, Wnt/β-catenin, and MAPK pathways. Other circRNAs can positively or negatively regulate tumor blood supply establishment and metastasis to influence GBM progression. CircRNAs are stable and present in numerous body fluids, and some are associated with tumor grade and outcomes, making them promising biomarkers. In addition, silencing or overexpressing certain circRNAs in patients may help treat GBM or improve patients’ responses to other treatments..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022
Radiation therapy might help, not harm, cancer cells
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Radiation therapy is a powerful way to kill cancer cells or slow their growth, but radiation can have unintended effects on surrounding cells. In a new study, researchers report that X-rays could actually help cancer cells gain a foothold in otherwise healthy tissue. The team blasted breast cancer cells cultured in the lab with different doses of X-rays. The cells released a cocktail of molecules in response including VEGF-A, a protein that triggers blood vessel formation. The team then transferred that molecular cocktail to healthy endothelial cells. Over time, those healthy cells showed a significantly enhanced ability to form the building blocks of blood vessels. This so-called “bystander effect” points to one way that cancer cells can cling to life even when zapped with radiation, and although the results are constrained to cells cultured in the lab, they could help inform researchers on how radiation therapy might do more harm than good..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/04/2020
Regulating metastatic potential in colorectal cancer
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Colorectal cancer is the second-leading cause of cancer-related deaths worldwide. Understanding tumor metastasis mechanisms and the interactions between cell types in the tumor microenvironment can help researchers identify treatment targets. Recently, a team of researchers examined the interaction between colorectal cancer cells and fibroblasts. IL-1α is a signaling protein that in other systems and cancers has both pro- and anti-metastasis effects. Here, the two highly metastatic colorectal cancer cell lines expressed IL-1α, while the less metastatic lines and fibroblasts did not. Increasing the abundance of IL-1α increased the expression of another signaling protein, CXCL12, in fibroblasts. This worked by either adding IL-1α directly or co-culturing fibroblasts with IL-1α-expressing cancer cells. Increasing the abundance of CXCL12, either directly or via co-culture, increased invasiveness of colorectal cancer cells and promoted angiogenesis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/17/2022
Sensory neurons from dorsal root ganglia regulate bone regeneration
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"While it might seem that bone must be solid to support our moving bodies, it's actually a dynamic tissue containing not only blood vessels but also nerves suggesting that they may have closely linked functions, particularly during bone formation and regeneration. A recent study evaluated the role of innervation on blood vessel formation during bone regeneration. Using a microfluidic culture system, researchers examined two types of cells from rats – sensory neurons, which convey neurological signals and endothelial cells, which are responsible for blood vessel generation and repair. They found that two neuropeptides – CGRP and SP – were secreted by sensory neurons when cultured with endothelial cells which drove an increase in markers of blood vessel formation in endothelial cells. The levels of tissue remodeling proteins called matrix metalloproteinases were also increased in endothelial cells..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
11/13/2020