This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"For the first time, scientists have figured out how to grow and extend the life of primary airway epithelial cells from newborns and young children. These cells line our nasal passages and lungs, protecting us from pathogens, and controlling our immune responses to allergens. Differences in these cells may help explain why certain infants develop wheezing and asthma later in life, but studying them has been challenging because they are difficult to obtain in babies and usually die in culture after dividing a few times. Now, researchers at Children’s National Medical Center in Washington, D.C. and George Washington University have devised a way to reprogram pediatric airway epithelial cells so that they survive, creating a new model to study respiratory disorders that take hold early in life. The team collected airway epithelial cells from 23 donors, including newborns, infants and young children..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The severity of allergic airway diseases, such as asthma, is affected by the interaction between genetics and the gut microbiome. Probiotic supplements are widely used and can alter the gut microbiome, but whether they can help prevent or alleviate allergic airway inflammation is unclear. The current study investigated the effects of gut microbiome modulation in two strains of mice: C57BL/6 mice and mice with increased susceptibility to airway inflammation (A/J mice). The susceptible A/J mice had less diverse gut microbiomes than the C57BL/6 mice and treatment with an acetate-producing probiotic altered the levels of certain bacteria differently in the different mouse strains. After airway inflammation was chemically induced, probiotic administration helped alleviate inflammation only in the susceptible A/J strain, partly by increasing acetate levels..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Growing up with siblings has many impacts on a child’s development and health, and previous studies suggest that this includes influencing their beneficial microbial communities. But a recent study examined these impacts directly, assessing the airway and gut microbiotas of nearly 700 children. In the COPSAC2010 cohort, the researchers followed the children from one week to six years of age. and found that the presence of siblings was among the most important factors influencing the composition of both microbial communities. This effect was most apparent in the first year of life, and while the number of older siblings had an impact, the age gap to the closest older sibling was a much stronger influence. It has previously been suggested that the microbial impact of siblings may reduce the incidence of ‘atopic diseases’ like asthma, allergy, and eczema, and in this study, having a sibling-influenced gut microbiota at one year old corresponded to reduced risk of asthma at six years old..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Our microbiome plays a key role in our health and contains bacteria, fungi, viruses, and archaea. However, due to several factors, the bacterial residents get the most attention. Consequently, our understanding of fungi and their interactions with other microbiome residents remains limited. A recent study addressed this by collecting data on the nasal cavity and oropharynx microbiome of healthy newborn infants. The fungal and bacterial species composition was most strongly influenced by location in the airway. However, breastfeeding status also significantly shaped both the bacterial and fungal communities in the oropharynx. Multi-kingdom microbial networks inference analysis suggested potential interactions between the fungi and bacteria. To examine potential impacts on the infants, the gene expression in their nasal cavity was also evaluated..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.